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Zyprexa alone, or in combination with lithium or valproate, is used for the short-term treatment of acute manic episodes associated with bipolar i disorder.

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Atypical antipsychotic drugs have been associated with metabolic changes including hyperglycemiadyslipidemiaand weight gainMetabolic changes may be associated with increased cardiovascular/cerebrovascular riskOlanzapine’s specific metabolic profile is presented below.

Orthostatic hypotension with antihypertensivesalcoholcautiondiazepamCaution with other CNS drugsanticholinergicshepatotoxic agentsConcomitant IV benzodiazepinenot recommended with IM olanzapineMay antagonize levodopadopamine agonistsMay be antagonized by rifampinomeprazolecarbamazepineothers that induce CYP1A2 or glucuronyl transferaseMay be potentiated by fluvoxamineothers that inhibit CYP1A2Smokers may have increased clearance.

Zyprexa can cause high blood sugarhyperglycemiaIf you are diabeticcheck your blood sugar levels on a regular basis while you are taking this medicine.

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